Control drug release of biodegradable polymers containing PEG-based additives
- Control drug release of biodegradable polymers containing PEG-based additives
- 김진향; 최지연; 박귀덕; 한동근
- Issue Date
- 2011 생체재료 아카데미 (2011 춘계생체재료학회)
- , 192-192
- From the results of drug release from SRL/PLGA coated on SS with or without additives, PLGA without additive showed a typical biphasic release kinetics such as a diffusion release (Phase 1), followed by a degradation release (Phase 2). PLGA containing water-soluble additives showed much faster drug release rate. The initial burst of SRL from PLGA with or without additive coated on SS showed 18, 21, and 34% at day 1, respectively. It is the reason why F127/PLGA is interconnected open pore structure that play a role as water channels for drug release. The amount of SRL remained in matrix after 6 weeks was also much larger in PLGA matrix than F68/PLGA and F127/PLGA. Therefore, we can control the drug release kinetics using hydrophilic additives embedded in the hydrophobic polymer matrix and obtain various patterns of drug release.
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