Sirolimus-eluting stent coated by ultrasonic spray and control drug release

Title
Sirolimus-eluting stent coated by ultrasonic spray and control drug release
Authors
장부남최지연강종희박귀덕노인섭한동근
Issue Date
2011-04
Publisher
2011년 춘계 학술대회 연구논문 초록집 (2011년 춘계 고분자학회)
Citation
, 122-123
Abstract
One of the solutions about in-stent restenosis and late thrombosis is to use drug that can prevent tissue hyperplasia followed by vascular injury in coronary stent. Sirolimus (SRL) is a popular drug for this purpose. In this study, SRL-loaded polymer coating on stent was carried out by ultrasonic spraying. In particular, top coating was applied for the control of SRL release from stent. In ultrasonic spraying, factors such as vibration frequency, gas pressure and solution concentration, were dominant in controlling the coating thickness and smoothness. From FE-SEM images, it was confirmed that the thickness of polymer layer was 5±1 µm. The loading amount of SRL was 100 μg/㎠. It was identified that top-coating and solvent system was affected by release behavior of SRL. Depending on the thickness and/or type of polymers, top-coating on drug-in-polymer layer produced significantly different release profiles. Solvent system influenced the release kinetics as well.
URI
http://pubs.kist.re.kr/handle/201004/39689
Appears in Collections:
KIST Publication > Conference Paper
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE