Tannic acid cross-linked gelatin-gum arabic coacervate microspheres for sustained release of allyl isothiocyanate: Characterization and in vitro release study
- Tannic acid cross-linked gelatin-gum arabic coacervate microspheres for sustained release of allyl isothiocyanate: Characterization and in vitro release study
- 장지강; 판철호; 정동화
- Allyl isothiocyanate; Complex coacervation; Tannic acid; Microspheres; Sustained release
- Issue Date
- Food research international
- VOL 44, NO 4, 1000-1007
- Tannic acid cross-linked gelatin–gum arabic coacervate microspheres, capable of sustained release of allyl
isothiocyanate (AITC) with high encapsulation efficiency, were developed for safe and efficient oral delivery of
AITC. The microspheres were spherical in shape and clustered. Statistical screening and optimization studies
revealed that a maximum AITC encapsulation efficiency could be obtained when the microspheres were
prepared with 4.5% total biopolymer, 6.5% oil, and 5.9% AITC in oil phase. Release studies showed that the
sustained release performance of the optimized microspheres was greatly enhanced by using more tannic
acid without loss in the encapsulation efficiency. The microspheres optimized with 1.5% tannic acid, having an
encapsulation efficiency of 83.75% and a mean cluster size of 116.80 μm, released 46% of encapsulated AITC
after 2 h in pepsin-containing simulated gastric fluid (pH 1.2), followed by releasing additional 48% in 6 h
after being transferred to pancreatin-containing simulated intestinal fluid (pH 7.5).
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