Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002
- Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002
- 박현봉; 양현옥; 이강노; 권학철
- New compound; Gombapyrone; Streptomyces; Microorganism; Bacterial metabolites; α-Pyrone; Polyene
- Issue Date
- VOL 16, NO 5, 3519-3529
- Microorganism-derived polyene polyketides have been shown to display a
variety of biological activities and have attracted great interest due to their structurally
intriguing chemical diversity. Two new polyenes were isolated from a culture broth of
Streptomyces sp. KMC-002 obtained from a soil sample in an abandoned mine. The
structures of these compounds were determined to be α-pyrone-containing polyene
analogues through analyses of HRFABMS, UV and NMR data, and were named
Gombapyrones E (1) and F (2). Gombapyrone E (1) showed antibacterial activity against
Micrococcus luteus, Enterococcus hirae, Staphylococcus aureus and MRSA.
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