A Regioselective Synthesis of E-Guggulsterone

Title
A Regioselective Synthesis of E-Guggulsterone
Authors
함정엽진정욱강헌중
Keywords
Guggulsterone; Inflammatory; Bowel diseases; regioselective synthesis; Oppenhauer oxidation
Issue Date
2011-05
Publisher
Molecules
Citation
VOL 16, 4165-4171
Abstract
We have successfully prepared E-guggulsterone from 16,17-epoxypregnenolone in 84% yield over two steps via a hydrazine reduction and Oppenhauer oxidation. Additionally, isomerization was induced by heat, light (hν) and acid catalysis to convert E- guggulsterone into the corresponding Z isomer.
URI
http://pubs.kist.re.kr/handle/201004/39771
ISSN
1420-3049
Appears in Collections:
KIST Publication > Article
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