Thermoreversible Radial Growth of Micellar Assembly for Hydrogel Formation Using Zwitterionic Oligopeptide Copolymer
- Thermoreversible Radial Growth of Micellar Assembly for Hydrogel Formation Using Zwitterionic Oligopeptide Copolymer
- 최보규; 조소혜; 이혜선; 차명화; 박귀덕; 정병문; 한동근
- Issue Date
- VOL 44, NO 7, 2269-2275
- Amphiphilic block copolymers can self-assemble
into micelles in water and can further form thermosensitive gels.
Here, we explored Pluronic F127 ABA triblock copolymer of
poly(ethylene glycol) (PEG; A) and poly(propylene glycol)
(PPG; B),modified with telechelic ionic peptides, either anionicGly-
Phe-Gly-Asp (GFGD) or zwitterionic Gly-Arg-Gly-Leu (GRGL)
or Gly-Arg-Gly-Asp (GRGD). All block copolymers formed
micelles, but only those bearing zwitterionic peptides formed
thermoreversible nanoassembly of micellar aggregates. These
aggregates facilitate to form a gel at high polymer concentrations, thus making the sol-to-gel transition temperature lower than F127
and FGM. An increase in the sol-to-gel transition temperature and a decrease in the gel modulus have been a concern for biomedical
applications of hydrophobically modified Pluronics. Current zwitterionic modified Pluronic F127, on the contrary, decreased the sol-to-gel
transition temperature without loss of the gelmodulus. The gelation, evidenced by cryo-transmission electronmicroscopy images, involves
radial growth of micelle aggregates, which is strikingly different from that of Pluronics driven by simple unimer-to-micelle transition. The
RGD-containing copolymer is of particular interest, in that it is cytocompatible and capable of binding to cell-surface adhesion receptors.
This work suggests a new platform in designing a temperature-sensitive polymer with a unique nanoassembly for tissue regeneration.
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