Thermoreversible Radial Growth of Micellar Assembly for Hydrogel Formation Using Zwitterionic Oligopeptide Copolymer

Title
Thermoreversible Radial Growth of Micellar Assembly for Hydrogel Formation Using Zwitterionic Oligopeptide Copolymer
Authors
최보규조소혜이혜선차명화박귀덕정병문한동근
Issue Date
2011-04
Publisher
Macromolecules
Citation
VOL 44, NO 7, 2269-2275
Abstract
Amphiphilic block copolymers can self-assemble into micelles in water and can further form thermosensitive gels. Here, we explored Pluronic F127 ABA triblock copolymer of poly(ethylene glycol) (PEG; A) and poly(propylene glycol) (PPG; B),modified with telechelic ionic peptides, either anionicGly- Phe-Gly-Asp (GFGD) or zwitterionic Gly-Arg-Gly-Leu (GRGL) or Gly-Arg-Gly-Asp (GRGD). All block copolymers formed micelles, but only those bearing zwitterionic peptides formed thermoreversible nanoassembly of micellar aggregates. These aggregates facilitate to form a gel at high polymer concentrations, thus making the sol-to-gel transition temperature lower than F127 and FGM. An increase in the sol-to-gel transition temperature and a decrease in the gel modulus have been a concern for biomedical applications of hydrophobically modified Pluronics. Current zwitterionic modified Pluronic F127, on the contrary, decreased the sol-to-gel transition temperature without loss of the gelmodulus. The gelation, evidenced by cryo-transmission electronmicroscopy images, involves radial growth of micelle aggregates, which is strikingly different from that of Pluronics driven by simple unimer-to-micelle transition. The RGD-containing copolymer is of particular interest, in that it is cytocompatible and capable of binding to cell-surface adhesion receptors. This work suggests a new platform in designing a temperature-sensitive polymer with a unique nanoassembly for tissue regeneration.
URI
http://pubs.kist.re.kr/handle/201004/39829
ISSN
0024-9297
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