Fabrication and Controlled Release of Electrosprayed ReoPro-loaded Metal Surface for Vascular Stent
- Fabrication and Controlled Release of Electrosprayed ReoPro-loaded Metal Surface for Vascular Stent
- 김동민; 이봉수; 강종희; 최지연; 박귀덕; 손태일; 정명호; 한동근
- stent; ReoPro (abciximab); poly(lactic-co-glycolic acid); poly(vinyl alcohol); emulsion; drug release
- Issue Date
- Macromolecular research
- VOL 19, NO 5, 501-506
- Metal stents have been very effective medical device for coronary artery disease. However, hyperplasia
proliferation of smooth muscle cells and late thrombus formation were the main causes of stent failure. To improve
the problem, an anti-platelet/anti-proliferative drug, ReoRro was used as a target drug for drug-eluting stent (DES).
An emulsion consisting of poly(lactic-co-glycolic acid) (PLGA), ReoRro, and poly(vinyl alcohol) (PVA) was electrosprayed
on the stainless steel (SS) specimen. Three specimens were tested: bare-metal SS, PLGA-coated SS, and
ReoRro-loaded SS. The surface morphology of polymer/ReoRro layer was smooth and the thickness was about 6
um. When different formulations of emulsion solution were examined with varying amounts of PVA (1, 5, 10%) or
ReoRro (10, 20, 30%), the release profiles were significantly affected by the two factors. More PVA content and
higher ReoPro concentration could accelerate the drug release in the given time period. Meanwhile, platelet adhesion
and smooth muscle cell (SMC) growth were significantly suppressed with the ReoPro-loaded specimens. The results
indicate that hydrophilic ReoPro release is controllable in the hydrophobic PLGA-based release system and the
released ReoRro can be effective in suppressing platelet adhesion and SMC overgrowth for vascular stents.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.