Fabrication and Controlled Release of Electrosprayed ReoPro-loaded Metal Surface for Vascular Stent

Title
Fabrication and Controlled Release of Electrosprayed ReoPro-loaded Metal Surface for Vascular Stent
Authors
김동민이봉수강종희최지연박귀덕손태일정명호한동근
Keywords
stent; ReoPro (abciximab); poly(lactic-co-glycolic acid); poly(vinyl alcohol); emulsion; drug release
Issue Date
2011-05
Publisher
Macromolecular research
Citation
VOL 19, NO 5, 501-506
Abstract
Metal stents have been very effective medical device for coronary artery disease. However, hyperplasia proliferation of smooth muscle cells and late thrombus formation were the main causes of stent failure. To improve the problem, an anti-platelet/anti-proliferative drug, ReoRro was used as a target drug for drug-eluting stent (DES). An emulsion consisting of poly(lactic-co-glycolic acid) (PLGA), ReoRro, and poly(vinyl alcohol) (PVA) was electrosprayed on the stainless steel (SS) specimen. Three specimens were tested: bare-metal SS, PLGA-coated SS, and ReoRro-loaded SS. The surface morphology of polymer/ReoRro layer was smooth and the thickness was about 6 um. When different formulations of emulsion solution were examined with varying amounts of PVA (1, 5, 10%) or ReoRro (10, 20, 30%), the release profiles were significantly affected by the two factors. More PVA content and higher ReoPro concentration could accelerate the drug release in the given time period. Meanwhile, platelet adhesion and smooth muscle cell (SMC) growth were significantly suppressed with the ReoPro-loaded specimens. The results indicate that hydrophilic ReoPro release is controllable in the hydrophobic PLGA-based release system and the released ReoRro can be effective in suppressing platelet adhesion and SMC overgrowth for vascular stents.
URI
http://pubs.kist.re.kr/handle/201004/39830
ISSN
1598-5032
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KIST Publication > Article
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