Mechanism of Albumin Release from Alginate and Chitosan Beads Fabricated in Dual Layers
- Mechanism of Albumin Release from Alginate and Chitosan Beads Fabricated in Dual Layers
- 남윤식; 배민수; 김성원; 노인섭; 서준교; 이강봉; 권일근
- alginate; chitosan; microspheres; protein delivery; carrier stability
- Issue Date
- Macromolecular research
- VOL 19, NO 5, 476-482
- Biocompatible polysaccharides, such as alginate and chitosan are widely used as drug carriers. Microspheres
based on the electrostatic interaction between these two polymers have been attractive as a means to deliver
protein drugs because the use of organic solvents can be avoided during their preparation. On the other hand, the
mechanisms for drug release, such as disintegration of microspheres, are not completely understood. This paper
examined the phenomena of disintegration of the core-shell type microspheres consisting of alginate and chitosan.
The microspheres formed by either chitosan-coated alginate or alginate-coated chitosan were generated using a labmade
instrument consisting of a syringe pump connected to a glass nozzle. Using fluorophore-labeled polysaccharides,
the disintegration of each polymer layer from the microspheres was monitored as a function of time. The alginate-
coated chitosan microspheres demonstrated enhanced stability with increasing concentration of the chitosan
core. The presence of an alginate shell itself also increased the stability of the microsphere compared to the microspheres
without an alginate coating. The chitosan concentration, however, did not have any effect on the stability of
the chitosan-coated alginate microspheres. The microspheres synthesized with alginate in the core demonstrated
concentration-dependent stability. In these microsphere experiments, the microsphere stability was found to be
related directly to the protein release kinetics. In the alginate/chitosan-based microspheres, the disintegration property
is the primary factor modulating the encapsulated drug release, which suggests the easiest simple method for
time-dependent protein drug delivery.
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