Real-time and non-invasive optical imaging of tumor-targeting glycol chitosan nanoparticles in various tumor models
- Real-time and non-invasive optical imaging of tumor-targeting glycol chitosan nanoparticles in various tumor models
- 나진희; 구희범; 이상민; 민경현; 박경순; 유현; 이성훈; 박재형; 권익찬; 정서영; 김광명
- Tumor-targeting; Nanoparticle; Brain cancer; Metastasis; Liver cancer
- Issue Date
- VOL 32, NO 22, 5252-5261
- Recently, various nanoparticle systems have been developed for tumor-targeted delivery of imaging
agents or drugs. However, large amount of them still have insufficient tumor accumulation and this
limits their further clinical applications. Moreover, the in vivo characteristics of nanoparticles have been
largely unknown, because there are few proper technologies to achieve the direct and non-invasive
characterization of nanoparticles in live animals. In this paper, we determined the key factors of nanoparticles
for in vivo tumor-targeting using our glycol chitosan nanoparticles (CNPs) which have proved
their tumor-targeting ability in many previous papers. For this study, CNPs were labeled with nearinfrared
fluorescence (NIRF) dye, Cy5.5 for in vivo analysis by non-invasive optical imaging techniques.
With these Cy5.5-CNPs, the factors such as in vitro/in vivo stability, deformability, and rapid uptake into
target tumor cells and their effects on in vivo tumor-targeting were evaluated in various tumor-bearing
mice models. In flank tumor models, Cy5.5-CNPs were selectively localized in tumor tissue than other
organs, and the real-time intravascular tracking of CNPs proved the enhanced permeation and retention
(EPR) effect of nanoparticles in tumor vasculature. Importantly, tumor-targeting CNPs showed an
excellent tumor-specificity in brain tumors, liver tumors, and metastasis tumor models, indicating their
great potential in both cancer imaging and therapy.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.