Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy

Title
Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy
Authors
정하영허명숙이소진구희범권익찬정서영김광명
Keywords
Photodynamic therapy; Human Serum Albumin Nanoparticles
Issue Date
2011-03
Publisher
Theranostics
Citation
VOL 1, 230-239
Abstract
Photodynamic therapy (PDT) is an emerging theranostic modality for various cancers and diseases. The focus of this study was the development of tumor-targeting albumin nanopar-ticles containing photosensitizers for efficient PDT. To produce tumor-targeting albumin nanoparticles, the hydrophobic photosensitizer, chlorin e6 (Ce6), was chemically conjugated to human serum albumin (HSA). The conjugates formed self-assembled nanoparticle struc-tures with an average diameter of 88 nm under aqueous conditions. As expected, the Ce6-conjugated HSA nanoparticles (Ce6-HSA-NPs) were nontoxic in their native state, but upon illumination with the appropriate wavelength of light, they produced singlet oxygen and damaged target tumor cells in a cell culture system. Importantly, when the nanoparticles were injected through the tail vein into tumor-bearing HT-29 mice, Ce6-HSA-NPs compared with free Ce6 revealed enhanced tumor-specific biodistribution and successful therapeutic results following laser irradiation. These results suggest that highly tumor-specific albumin nanopar-ticles have the potential to serve not only as efficient therapeutic agents, but also as photo-dynamic imaging (PDI) reagents in cancer treatment.
URI
http://pubs.kist.re.kr/handle/201004/40006
ISSN
18387640
Appears in Collections:
KIST Publication > Article
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