Facile Method for Development of Ligand-Patterned Substrates Induced by a Chemical Reaction

Title
Facile Method for Development of Ligand-Patterned Substrates Induced by a Chemical Reaction
Authors
서현정최인성이정욱김소현김동은김상경여운석
Keywords
질량분석; 단백질 정량; MALDI-MS; SAM; Isotope label; aptamers; cell adhesion; mass spectrometry; monolayers; patterning
Issue Date
2011-05
Publisher
Chemistry : a European journal
Citation
VOL 17, NO 21, 5804-5807
Abstract
In conclusion, this report describes a simple ligand-patterning strategy induced by a chemical reaction that generates a pattern of amine functional groups. We proved the fidelity of our strategy by demonstrating the RGD patterning and subsequent cell patterns and the capture of prostate cancer cells to a specific aptamer-patterned substrate. Due to the chemical flexibility of the resulting amine functional group and the compatibility of this strategy with many existing patterning methods, we believe that this method will be a useful platform technology for the preparation of ligandpatterned substrates. For example, we are currently carrying out nano-patterning of multiple ligands by using grafting dip-pen nanolithography for investigation of cellular behavior on multi-ligand-presenting substrates.
URI
http://pubs.kist.re.kr/handle/201004/40066
ISSN
0947-6539
Appears in Collections:
KIST Publication > Article
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