Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지훈 | - |
dc.contributor.author | 이양기 | - |
dc.contributor.author | Kaushik Singha | - |
dc.contributor.author | 김현우 | - |
dc.contributor.author | 신재호 | - |
dc.contributor.author | 조성봉 | - |
dc.contributor.author | 한동근 | - |
dc.contributor.author | 김원종 | - |
dc.date.accessioned | 2015-12-03T00:39:50Z | - |
dc.date.available | 2015-12-03T00:39:50Z | - |
dc.date.issued | 201106 | - |
dc.identifier.citation | VOL 22, NO 6, 1031-1038 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.other | 35366 | - |
dc.identifier.uri | http://pubs.kist.re.kr/handle/201004/40162 | - |
dc.description.abstract | In recent years, numerous research activities have been devoted to the controlled release of nitric oxide (NO) due to its potential as a restenosis inhibitor which inhibits the proliferation of vascular smooth muscle cells, the apoptosis of vascular endothelial cells, and aggregation of platelets. This work has demonstrated the development of a novel NO-conjugated gel system comprising of thermosensitive Pluronic F127, branched polyethylenimine (BPEI), and diazeniumdiolates (NONOates). Synthesis of conjugated Pluronic- BPEI-NONOates involved coupling of activated F127 to BPEI followed by the installation of NONOates at the secondary amine sites of branched PEI backbone under high pressure. NO-conjugated gel system, F127-BPEI-NONOates, reduced the initial burst of NO release and prolonged NO release. Furthermore, F127-BPEI-NONOates polymer coated on cell culture dish displayed much higher increase of endothelial cell proliferation and reduction of smooth muscle cell proliferation than that exhibited by non-NO releasing control. Such an NO-releasing device can operate locally and has a great potential in several biomedical applications due to high biocompatibility imparted by the conjugated F127. | - |
dc.publisher | Bioconjugate chemistry | - |
dc.title | NONOates-Polyethylenimine Hydrogel for Controlled Nitric Oxide Release and Cell Proliferation Modulation | - |
dc.type | Article | - |
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