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dc.contributor.author김지훈-
dc.contributor.author이양기-
dc.contributor.authorKaushik Singha-
dc.contributor.author김현우-
dc.contributor.author신재호-
dc.contributor.author조성봉-
dc.contributor.author한동근-
dc.contributor.author김원종-
dc.date.accessioned2015-12-03T00:39:50Z-
dc.date.available2015-12-03T00:39:50Z-
dc.date.issued201106-
dc.identifier.citationVOL 22, NO 6, 1031-1038-
dc.identifier.issn1043-1802-
dc.identifier.other35366-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/40162-
dc.description.abstractIn recent years, numerous research activities have been devoted to the controlled release of nitric oxide (NO) due to its potential as a restenosis inhibitor which inhibits the proliferation of vascular smooth muscle cells, the apoptosis of vascular endothelial cells, and aggregation of platelets. This work has demonstrated the development of a novel NO-conjugated gel system comprising of thermosensitive Pluronic F127, branched polyethylenimine (BPEI), and diazeniumdiolates (NONOates). Synthesis of conjugated Pluronic- BPEI-NONOates involved coupling of activated F127 to BPEI followed by the installation of NONOates at the secondary amine sites of branched PEI backbone under high pressure. NO-conjugated gel system, F127-BPEI-NONOates, reduced the initial burst of NO release and prolonged NO release. Furthermore, F127-BPEI-NONOates polymer coated on cell culture dish displayed much higher increase of endothelial cell proliferation and reduction of smooth muscle cell proliferation than that exhibited by non-NO releasing control. Such an NO-releasing device can operate locally and has a great potential in several biomedical applications due to high biocompatibility imparted by the conjugated F127.-
dc.publisherBioconjugate chemistry-
dc.titleNONOates-Polyethylenimine Hydrogel for Controlled Nitric Oxide Release and Cell Proliferation Modulation-
dc.typeArticle-
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