Sodium Benzoate-mediated Cytotoxicity in Mammalian Cells

Title
Sodium Benzoate-mediated Cytotoxicity in Mammalian Cells
Authors
박혜원박에드윈윤형문임혜원
Issue Date
2011-08
Publisher
Journal of food biochemistry
Citation
VOL 35, NO 4, 1034-1046
Abstract
Sodium benzoate (SB) is widely used in food chemistry, cosmetics and the pharmaceutical industry. Previous studies suggest possible toxic effects of SB when used as a food preservative. However, these studies were confined to microbiological systems. Therefore, we investigated the cytotoxic effects of SB in rat-cultured cortical neurons and in human clonal epithelial cells (HeLa cells) using cell death assays and the fluorescent measurements of intracellular Ca2+concentration ([Ca2+]i) and mitochondrial transmembrane potential (ΔΨm). We found that SB induced cell death in a dose-dependent manner. Even 0.1% (w/v) SB, a concentration typically added to soft drinks, produced a significant decrease in cell viability in rat cortical and HeLa cells. We also found that SB caused [Ca2+]i and ΔΨm increases in a dose-dependent manner. Based on our results, more caution and further cellular studies are required with respect to the use of SB as a food preservative.
URI
http://pubs.kist.re.kr/handle/201004/40241
ISSN
0145-8884
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KIST Publication > Article
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