Sodium Benzoate-mediated Cytotoxicity in Mammalian Cells
- Sodium Benzoate-mediated Cytotoxicity in Mammalian Cells
- 박혜원; 박에드윈; 윤형문; 임혜원
- Issue Date
- Journal of food biochemistry
- VOL 35, NO 4, 1034-1046
- Sodium benzoate (SB) is widely used in food chemistry, cosmetics and the
pharmaceutical industry. Previous studies suggest possible toxic effects of SB
when used as a food preservative. However, these studies were confined to
microbiological systems. Therefore, we investigated the cytotoxic effects of SB
in rat-cultured cortical neurons and in human clonal epithelial cells (HeLa
cells) using cell death assays and the fluorescent measurements of intracellular
Ca2+concentration ([Ca2+]i) and mitochondrial transmembrane potential
(ΔΨm). We found that SB induced cell death in a dose-dependent manner. Even
0.1% (w/v) SB, a concentration typically added to soft drinks, produced a
significant decrease in cell viability in rat cortical and HeLa cells. We also
found that SB caused [Ca2+]i and ΔΨm increases in a dose-dependent manner.
Based on our results, more caution and further cellular studies are required
with respect to the use of SB as a food preservative.
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