Gypenoside TN-2 ameliorates scopolamine-induced learning deficit in mice

Title
Gypenoside TN-2 ameliorates scopolamine-induced learning deficit in mice
Authors
Sung-Woon HongJeong-hwa YangEun-Ha Joh김형자Dong-Hyun Kim
Keywords
Gynostemma pentaphyllum (Thunb.) Makino Gypenoside TN-2; Memory; Scopolamine; Brain-derived neurotrophic factor
Issue Date
2011-04
Publisher
Journal of ethnopharmacology
Citation
VOL 134, NO 3, 1010-1013
Abstract
Ethnopharmacological relevance: Gynostemma pentaphyllum (Thunb.) Makino (GP, family Cucurbitaceae), which contains dammarane saponins as its main constituents, is used in China, Japan, and Korea as a traditional medicine to treat cancer, obesity, arteriosclerosis, asthma and senility. Aim of the study: To investigate the memory-enhancing effects of GP, Gypenoside TN-2 (TN-2) was isolated by activity-guided fractionation and administered to scopolamine-induced memory-deficient mice. Materials and methods: The memory-enhancing effects of TN-2 were evaluated using passive avoidance, Y-maze, and Morris water maze tests, and the protein expressions of brain-derived neurotrophic factor (BDNF), cAMP element binding protein (CREB), and p-CREB were determined by immunoblotting. Results: TN-2 inhibitedmemoryand learning deficits in scopolamine treated mice in the passive avoidance test. TN-2 (10, 20, and 40 mg/kg, p.o.) significantly inhibited memory and learning deficits in the passive avoidance test by 40%, 96% and 78%, respectively, and exhibited significant memory-enhancing effects on the Y-maze test and the Morris water maze test. TN-2 also markedly increased BNDF expression and activated the transcription factor CREB in the hippocampi of scopolamine-treated mice. Conclusions: TN-2 may ameliorate memory and learning deficits by activating the CREB-BDNF pathway.
URI
http://pubs.kist.re.kr/handle/201004/40251
ISSN
0378-8741
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KIST Publication > Article
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