Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs

Title
Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs
Authors
육순홍오근상구희범전혜성김광명권익찬
Keywords
Drug delivery; Multi-core vesicle nanoparticles; Pluronic; Docetaxel; Chemotherapy
Issue Date
2011-11
Publisher
Biomaterials
Citation
VOL 32, NO 31, 7924-7931
Abstract
The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTXloaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multicore vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a noninvasive live animal imaging technology.
URI
http://pubs.kist.re.kr/handle/201004/40296
ISSN
0142-9612
Appears in Collections:
KIST Publication > Article
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