Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs
- Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs
- 육순홍; 오근상; 구희범; 전혜성; 김광명; 권익찬
- Drug delivery; Multi-core vesicle nanoparticles; Pluronic; Docetaxel; Chemotherapy
- Issue Date
- VOL 32, NO 31, 7924-7931
- The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG,
molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTXloaded
Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were
incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multicore
vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core
vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was
observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into
the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo
biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a noninvasive
live animal imaging technology.
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