Youngia denticulata Protects Against Oxidative Damage Induced by tert-Butylhydroperoxide in HepG2 Cells

Title
Youngia denticulata Protects Against Oxidative Damage Induced by tert-Butylhydroperoxide in HepG2 Cells
Authors
강경수조은혜이희주사랑게렐윤지호김철영유지혜김영진김종환안수용노주원
Keywords
antioxidant; apoptosis; comet assay; functional food; hepatoprotection; wild vegetable; Youngia denticulata Kitam
Issue Date
2011-10
Publisher
Journal of medicinal food
Citation
VOL 14, NO 10, 1198-1207
Abstract
Improvement of liver function is one of the most popular commercial health claims of functional foods in Asian countries, including Korea. After examining the potential of several traditional Korean wild vegetables for enhancing liver function, we found that Youngia denticulata Kitam. has strong hepatoprotective effects against oxidative stress induced by tert-butylhydroperoxide (t-BHP). We are the first to report that the extract and ethyl acetate fractions of Y. denticulata have radical scavenging activities and inhibit oxidative stress–induced cell death and DNA damage in HepG2 cells. The extract and ethyl acetate fractions significantly decreased cellular reactive oxygen species production and apoptosis induced by t-BHP in HepG2 cells. In addition, they prevented the depletion of cellular glutathione, which is an important defense molecule against oxidizing xenobiotics. Chlorogenic acid and 3,5-dicaffeoylquinic acid were found to be major active components responsible for the activity of Y. denticulata and could serve as marker compounds for standardization. These data suggest that Y. denticulata could be promoted as a potential antioxidative functional food candidate, particularly for hepatoprotection against oxidative stress.
URI
http://pubs.kist.re.kr/handle/201004/40312
ISSN
1096-620X
Appears in Collections:
KIST Publication > Article
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