High-frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage
- High-frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage
- 윤정훈; 조제원; 김남곤; 김대덕; 이은숙; 천창율; 권영우
- microwave ablation; breast cancer; planar coaxial probebased applicator; collateral damage; nude mouse xenograft model
- Issue Date
- International journal of cancer: Journal international du cancer
- VOL 129, NO 8, 1970-1978
- To overcome the limits of conventional microwave ablation, a new frequency spectrum above 6 GHz has been explored for
low-power and low collateral damage ablation procedure. A planar coaxial probe-based applicator, suitable for easy insertion
into the human body, was developed for our study to cover a wideband frequency up to 30 GHz. Thermal ablations with small
input power (1–3 W) at various microwave frequencies were performed on nude mice xenografted with human breast cancer.
Comparative study of ablation efficiencies revealed that 18-GHz microwave results in the largest difference in the temperature
rise between cancer and normal tissues as well as the highest ablation efficiency, reaching 20 times that of 2 GHz. Thermal
profile study on the composite region of cancer and fat also showed significantly reduced collateral damage using 18 GHz.
Application of low-power (1 W) 18-GHz microwave on the nude mice xenografted with human breast cancer cells resulted in
recurrence-free treatment. The proposed microwave ablation method can be a very effective process to treat small-sized tumor
with minimized invasiveness and collateral damages.
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