High-frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Title
High-frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage
Authors
윤정훈조제원김남곤김대덕이은숙천창율권영우
Keywords
microwave ablation; breast cancer; planar coaxial probebased applicator; collateral damage; nude mouse xenograft model
Issue Date
2011-10
Publisher
International journal of cancer: Journal international du cancer
Citation
VOL 129, NO 8, 1970-1978
Abstract
To overcome the limits of conventional microwave ablation, a new frequency spectrum above 6 GHz has been explored for low-power and low collateral damage ablation procedure. A planar coaxial probe-based applicator, suitable for easy insertion into the human body, was developed for our study to cover a wideband frequency up to 30 GHz. Thermal ablations with small input power (1–3 W) at various microwave frequencies were performed on nude mice xenografted with human breast cancer. Comparative study of ablation efficiencies revealed that 18-GHz microwave results in the largest difference in the temperature rise between cancer and normal tissues as well as the highest ablation efficiency, reaching 20 times that of 2 GHz. Thermal profile study on the composite region of cancer and fat also showed significantly reduced collateral damage using 18 GHz. Application of low-power (1 W) 18-GHz microwave on the nude mice xenografted with human breast cancer cells resulted in recurrence-free treatment. The proposed microwave ablation method can be a very effective process to treat small-sized tumor with minimized invasiveness and collateral damages.
URI
http://pubs.kist.re.kr/handle/201004/40331
ISSN
0020-7136
Appears in Collections:
KIST Publication > Article
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