NO delivery by NONOates-conjugated Pluronic hydrogel for controlling cell proliferation
- NO delivery by NONOates-conjugated Pluronic hydrogel for controlling cell proliferation
- 김지훈; 이양기; Kaushik Singha; 김현우; 한동근; 김원종
- Issue Date
- 제 3회 아시아 생체재료학회
- Over the last decade, percutaneous transluminal coronary angioplasty (PTCA) has been used to patients with cardiovascular and coronary artery disease over 20 years, but this technique causes patients’ suffer and fear from reoccurrence of stenosis, restenosis, after implantation of stents. Because general drug-eluting stents, paclitaxel and doxorubicin loaded stents, damage vascular endothelial cells as well as vascular smooth muscle cells although these show decreased restenosis, cell-specific modulating coating-materials hold the spotlight. Nitric oxide (NO), which is produced by NOSs (nitric oxide synthase) in vivo, has been shown to modulate cells specifically when delivering appropriate dose; reducing the proliferation of smooth muscle cells and enhancing the proliferation of vascular endothelial cells. However, in general method, fast NO release of NO donor is a disadvantage for further application.
In the experiment, we demonstrated the development of novel NO-conjugated gel system comprising of thermosensitive Pluronic F127, branched polyethylenimine (BPEI) and diazeniumdiolates (NONOates; 1-substituted diazen-1-ium-1,2 diolates). Then we confirmed the release patterns and cell-specific proliferation of endothelial cells and smooth muscle cells in vitro. Therefore, we could make thermo-sensitive nitric oxide-releasing donor and conclude that this technique has a great potential in several biomedical applications, especially in stents.
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