Fabrication and controlled drug release of novel dual drug-eluting stents

Fabrication and controlled drug release of novel dual drug-eluting stents
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제 3회 아시아 생체재료학회
The thrombus formation and the proliferation of the smooth muscle cells induced by injury after angioplasty of metal stents have generated in-stent restenosis inside them.1 To solve these problems, self-degradable scaffolds needs to develop to deliver bioactive agents blocking/inhibiting the proliferation of the cells. Biodegradable and biocompatible polymers were used as a drug carrier for both alpha-lipoic acid (ALA) and ReoPro. Main function of ALA is to increase production of glutathione and ReoPro is a potent inhibitor that blocks the final pathway of platelet aggregation.2 Since drug-eluting stent (DES) has been used for the patients of coronary artery disease, a novel concept of stent can significantly improve the coronary occlusion and restenosis. In this study a hierarchical structure composed of three layers such as top, barrier, and bottom was formed on the stent surface using electrospraying or ultrasonic nanocoating. The release behaviors of dual drugs are of particular interest. The thickness of each layer was about 4~6 μm and the whole thickness was less than 15 μm. The release behaviors of dual drugs were significantly affected by the presence of a barrier layer within the polymer coating matrix. Current design of polymer coating may be useful in delivering multiple drugs at a time from DES.
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