Total Synthesis of Natural Product and its Derivatives via Suzuki-Miyaura Cross-Coupling Reaction

Title
Total Synthesis of Natural Product and its Derivatives via Suzuki-Miyaura Cross-Coupling Reaction
Authors
정규혁김태정이우정김수남함정엽
Keywords
Suzuki-Miyaura Cross-Coupling; Amorphastilbol; Peroxisome proliferator?ctivated receptors; Robinia pseudo-acacia var. umbraculifera; PPAR γ agonist; anti-diabetes; anti-obesity
Issue Date
2011-08
Publisher
2011년 대한화학회 유기분과 하계 워크샵
Abstract
Peroxisome proliferator–activated receptors (PPARs) are ligand-activated transcription factors involved in the transcriptional regulation of key metabolic pathways such as lipid metabolism, adipogenesis, and insulin sensitivity. Three PPAR isotypes have been identified α, γ, and δ. The Amorphastilbol (APH) is a small molecules of natural stilbenes isolated from the Acacia tree Robinia pseudo-acacia var. umbraculifera. It was identified that Amorphastilbol has an activity for PPAR γ agonist. Therefore, we synthesized Amorphastilbol and its unnatural derivatives. Some of compounds showed good activity as PPAR γ agonist. Herein we wish to describe syntheses of Amorphastilbol derivatives and their biological potency of PPAR γ.
URI
http://pubs.kist.re.kr/handle/201004/40441
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KIST Publication > Conference Paper
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