Immunostick assay for medical diagnosis of rheumatoid arthritis

Title
Immunostick assay for medical diagnosis of rheumatoid arthritis
Authors
고혁이은행전병진최혜진강민정변재철
Keywords
Immunoassay; Medical Diagnosis; Rhematoid Arthritis; Stick; immunostick; cyclic-citrullinated peptide; rheumatoid arthritis
Issue Date
2011-12
Publisher
Biotechnology and bioprocess engineering
Citation
VOL 16, NO 6, 1248-1253
Abstract
An immunoassay based on stick-type solid support (immunostick assay) was developed. To demonstrate the medical diagnosis of rheumatoid arthritis (RA), cyclic-citrullinated peptide (CCP), one of specific antigens against RA autoantibodies, was immobilized on the surface of the immunostick, and a color index table was prepared for the determination of CCP-positivity of the test sera. The positivity of RA-positive (n = 31) and RA-negative (n = 20) sera was tested using the immunostick assay and a conventional enzyme-linked immunosorbent assay (ELISA). The statistical agreement of the test results from both methods was analyzed using inter-rater coefficient kappa and Bland-Altman test. The immunostick assay with a color index table was determined to have a high statistical correlation to the conventional ELISA method.
URI
http://pubs.kist.re.kr/handle/201004/40500
ISSN
1226-8372
Appears in Collections:
KIST Publication > Article
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