Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.

Title
Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
Authors
김성환고현석방혜선박선희김동규권학철김선여신종헌오동찬
Keywords
New Compound; Coprismycin; Neuroprotection; Microorganism; Dung Beetle; Streptomyces; Phenylpyridine; Neuroprotective activity; Copris tripartitus
Issue Date
2011-10
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 21, NO 19, 5715-5718
Abstract
Two new phenylpyridines, named coprismycins A and B (1 and 2), and previously reported dipyridines (3–6) were isolated from a culture of Streptomyces sp. associated with the dung beetle, Copris tripartitus. The structures of the coprismycins (1 and 2) were elucidated by the analysis of 1D and 2D NMR spectra and mass, UV, and IR spectra. Coprismycins A-B (1 and 2) and dipyridines (5 and 6) displayed comparable neuroprotective effects against MPP+ (1-methyl-4-phenylpyrimidium)-induced neurotoxicity in neuroblastoma SH-SY5Y cells.
URI
http://pubs.kist.re.kr/handle/201004/40531
ISSN
0960-894X
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KIST Publication > Article
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