Biological activities of alcohol extracts of some plants collected from Saudi Arabia
- Biological activities of alcohol extracts of some plants collected from Saudi Arabia
- 이주영; 배덕성; 김영훈; 이재권; Hossam Abdallah; Essam Abdel-Sattar; 판철호
- Saudi plants; antioxidant; AKR1B1; AKR1B10
- Issue Date
- 2011 International Symposium & Annual Meeting of the KSABC
- Saudi Arabia is rich in desert flora. Especially in the western regions, more than 4000 species have been found. The flora is specific to Saudi Arabia in great number of plants. Even the plants grow in other countries, from our previous experience with Saudi plants, they showed different spectrum of constituents either in the amount or in the presence of new compounds with different stereo configuration. In spite of previous investigation of a great number of Saudi plants, they still need detailed investigation with focusing on their biological evaluation. In this study, alcohol extracts prepared from 51 Saudi plants were examined for their antioxidant activity, inhibitory effects on recombinant human AKR1B1 (rhAKR1B1) and AKR1B10 (rhAKR1B10), and inhibition of NO production in LPS-stimulated murine macrophage Raw 264.7 cells. Eight extracts showed more than 80% of ABTS radical scavenging activity at 100 ㎍/mL, 5 and 3 extracts inhibited more than 50% of rhAKR1B1 and rhAKR1B10 activity, respectively, at 10 ㎍/mL, and 10 extracts inhibited the NO production without any cytotoxicity at 20 ㎍/mL. (SRAA)
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- KIST Publication > Conference Paper
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