Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors

Title
Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors
Authors
Zhiguo Liu이우정김수남윤구천승훈
Keywords
bromo-retrochalcone; ptp1b; diabetes; insulin; Protein tyrosine phosphatase 1B; Licochalcone; Synthetic
Issue Date
2011-06
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 21, NO 12, 3755-3758
Abstract
A series of bromo-retrochalcones was designed, synthesized and evaluated as PTP1B inhibitors based on licochalcone A and E. Compounds 6, 12, 13, 14, 25, 36, 37, 39, and 41 showed potent inhibitory effects against PTP1B, and compound 37, the most potent among the series, had an IC50 value of 1.9 μlM, about two-fold better than that of the positive control, ursolic acid.
URI
http://pubs.kist.re.kr/handle/201004/40629
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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