Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines against Melanoma Cell Line

Title
Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines against Melanoma Cell Line
Authors
안혜미이준아김환오창현이소하심태보하정미김동진유경호
Keywords
Pyridinylcarbonylpyrimidines; Antiproliferative activity; Melanoma cell line
Issue Date
2011-04
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 32, NO 4, 1209-1214
Abstract
The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described. Among them, three compounds 1e, 1h, and 1o showed superior antiproliferative activities to Sorafenib (IC50 = 5.5 μM) as a reference compound. In our series, urea compound 1o having 4-chloro-3- trifluoromethyl moiety on the benzene nucleus exhibited very good antiproliferative activity with IC50 value of 1.4 μM.
URI
http://pubs.kist.re.kr/handle/201004/40816
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
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