Pyrogallin, an ATP-competitive inhibitor of JAK3

Title
Pyrogallin, an ATP-competitive inhibitor of JAK3
Authors
이병일안형준한기철안대로Dongyun Shin
Keywords
Tyrosine kinase; JAK3; Pyrogallin; Inhibitor; Immune
Issue Date
2011-03
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 32, NO 3, 1077-1079
Abstract
In summary, we have screened a chemical library to find hit compounds for development of JAK3 inhibitors. As a result, pyrogallin, a natural product was demonstrated to show an inhibitory effect on JAK3. Due to its structural similarity to ATP, pyrogallin likely inhibits JAK3with anATP-competitivemode. Based on the docking experiment, we further found that amino acid residues in the active sitemight interact with a certain point of pyrogallin, which would hold great promise for specific inhibition of JAK3 through elaborate chemical modifications.
URI
http://pubs.kist.re.kr/handle/201004/40980
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
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