Two Unsaturated Fatty Acids with Potent α-Glucosidase Inhibitory Activity Purified from the Body Wall of Sea Cucumber (Stichopus japonicus)

Title
Two Unsaturated Fatty Acids with Potent α-Glucosidase Inhibitory Activity Purified from the Body Wall of Sea Cucumber (Stichopus japonicus)
Authors
The Han Nguyen엄병헌Sang Moo Kim
Keywords
diabetes; fatty acid; kinetics; sea cucumber; α-Glucosidase; inhibitor
Issue Date
2011-11
Publisher
Journal of food science : an official publication of the Institute of Food Technologists
Citation
VOL 76, NO 9, H208-H214
Abstract
One therapeutic approach for preventing diabetes mellitus and obesity is to retard the absorption of glucose via inhibition of α-glucosidase. Two unsaturated fatty acids with strong α-glucosidase inhibitory activity, 7(Z)-octadecenoic acid (1) and 7(Z),10(Z)-octadecadienoic acid (2), were purified from the body wall of Stichopus japonicus. IC50 values of compounds 1 and 2 were 0.51 and 0.67 μg/mL against Saccharomyces cerevisiae α-glucosidase and 0.49 and 0.60 μg/mL against Bacillus stearothermophilus α-glucosidase, respectively. These compounds mildly inhibited rat-intestinal sucrase and maltase. In addition, both compounds showed a mixed type of inhibition against S. cerevisiae α-glucosidase and were very stable under thermal and acidic conditions up to 60 min. The KI and KIS values of compounds 1 and 2 were 0.44 and 0.22 μg/mL, and 0.39 and 0.13 μg/mL, respectively.
URI
http://pubs.kist.re.kr/handle/201004/41034
ISSN
0022-1147
Appears in Collections:
KIST Publication > Article
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