PREPARATION OF LACTIDE-GRAFTED MAGNESIUM OXIDE NANOPARTICLES AND THEIR EFFECT ON pH NEUTRALIZATION

Title
PREPARATION OF LACTIDE-GRAFTED MAGNESIUM OXIDE NANOPARTICLES AND THEIR EFFECT ON pH NEUTRALIZATION
Authors
금창헌최지연김준태박귀덕안동준한동근
Issue Date
2011-11
Publisher
The 12th Pacific Polymer Conference
Abstract
Biodegradable polymers such as poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) have been attracted in various biomedical applications. However, degradation of polyester can decrease the mechanical properties and increase the acidity of the environment which can induce inflammation. In order to neutralize the acidic environment caused during polymer degradation, L-lactide (LA) was grafted on the surface of MgO nanoparticles via surface-initiated ring-opening polymerization. The PLLA-grafted MgO nanoparticles were characterized by FTIR, SEM, pH meter, and TGA. Surface-modified MgO nanoparticles showed pH neutralization effect and increased the pH with the MgO concentration. The surface-modified MgO nanoparticles-reinforced PLLA composites were also fabricated and their modulus increased significantly compared to those of the control PLLA. MgO nanoparticles-reinforced PLLA composites demonstrated great potential as biodegradable and biocompatible stents or implants which can avoid inflammation.
URI
http://pubs.kist.re.kr/handle/201004/41040
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KIST Publication > Conference Paper
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