Synthesis and Characterization of Thermosensitive Poly(organophosphazene) Gels with an Amino Functional Group

Title
Synthesis and Characterization of Thermosensitive Poly(organophosphazene) Gels with an Amino Functional Group
Authors
이배훈송수창
Keywords
polyphosphazenes; gels; biomaterials; biodegradable; stimuli-sensitive polymers
Issue Date
2011-04
Publisher
Journal of applied polymer science
Citation
VOL 120, NO 2, 998-1005
Abstract
Thermosensitive poly(organophosphazene) gels have been synthesized with a host of side groups, including α-amino-ω-methoxy-poly(ethylene glycol), hydrophobic amino acid esters (PheOEt, LeuOEt, and IleuOEt), depsipeptide ethyl ester (GlyGlycOEt), and lysine ethyl ester (lysOEt). The fraction of the last side group, lysOEt, which possesses two amine functional groups, was designed to be in the range of 0.1–0.3 mol per polymer unit. The poly(organophosphazenes) have been characterized via 1H- and 31P-NMR spectroscopies, GPC, and elemental analysis. The phase transition behavior of the poly(organophosphazenes) in aqueous solution has been determined via viscometry. Some of the poly(organophosphazenes) with amino functional groups exhibit reversible sol–gel transitions at temperatures near those of the human body, when in aqueous solution. These polymers form a sol at lower temperatures, and become gels at higher temperatures. Also, these polymer solutions have been found to behave generally like Newtonian fluids in the sol state, but appear to exhibit pseudoplastic qualities in the gel state. The polymers possessing depsipeptide ethyl esters (ethyl-2-(O-glycyl)glycolate) as a side group tend to exhibit much higher degradation rates under physiological conditions than do those which lack the depsipeptide ethyl ester group.
URI
http://pubs.kist.re.kr/handle/201004/41060
ISSN
0021-8995
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE