Synthesis and Characterization of Thermosensitive Poly(organophosphazene) Gels with an Amino Functional Group
- Synthesis and Characterization of Thermosensitive Poly(organophosphazene) Gels with an Amino Functional Group
- 이배훈; 송수창
- polyphosphazenes; gels; biomaterials; biodegradable; stimuli-sensitive polymers
- Issue Date
- Journal of applied polymer science
- VOL 120, NO 2, 998-1005
- Thermosensitive poly(organophosphazene)
gels have been synthesized with a host of side groups,
including α-amino-ω-methoxy-poly(ethylene glycol),
hydrophobic amino acid esters (PheOEt, LeuOEt, and
IleuOEt), depsipeptide ethyl ester (GlyGlycOEt), and lysine
ethyl ester (lysOEt). The fraction of the last side group,
lysOEt, which possesses two amine functional groups, was
designed to be in the range of 0.1–0.3 mol per polymer unit.
The poly(organophosphazenes) have been characterized via
1H- and 31P-NMR spectroscopies, GPC, and elemental analysis.
The phase transition behavior of the poly(organophosphazenes)
in aqueous solution has been determined via
viscometry. Some of the poly(organophosphazenes) with
amino functional groups exhibit reversible sol–gel transitions
at temperatures near those of the human body, when in
aqueous solution. These polymers form a sol at lower temperatures,
and become gels at higher temperatures. Also,
these polymer solutions have been found to behave generally
like Newtonian fluids in the sol state, but appear to exhibit
pseudoplastic qualities in the gel state. The polymers
possessing depsipeptide ethyl esters (ethyl-2-(O-glycyl)glycolate)
as a side group tend to exhibit much higher degradation
rates under physiological conditions than do those
which lack the depsipeptide ethyl ester group.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.