Effect of chronic stress on CA1 place cell activities in freely moving mice

Effect of chronic stress on CA1 place cell activities in freely moving mice
Issue Date
2011 Neuroscience 학회
Chronic stress can be particularly debilitating the hippocampal function such as spatial learning and memory. Although stress effects on hippocampal plasticity and memory have been well studied, much less is known about chronic stress effects on hippocampal place cell activities in behaving animals. Here we investigated whether chronic restraint stress (6 hr/a day for 21 days) would impair spatial learning performance on Morris water maze test for 7 days and also affect hippocampal place cell activities in CA1 region (the mice received restraint stress until the end of each experiment). After chronic restraint stress for 21 days, the corticosteroid stress hormone was elevated and the stress group showed significant retarded learning performance on 7 days Morris water maze test compare to the control group. Place cells were recorded in an open-field cylindrical chamber. Three recording sessions were conducted on each experiment. On the inside of the chamber, a rectangular white card board was installed as a local cue. Cue arrangements were identical in session 1 and 3 while a local cue was 90° rotated in session 2. The stress group showed the low similarities in the same environments (session 1 & 3) compare to the control group. In addition, the average firing rate of the place cells was significantly reduced and place field was small in the stress group. Also the spatial coherence was significantly lower in the stress group. These results suggest that chronic stress can induce alterations in hippocampal place cell activities, which could lead to impairment of spatial learning and memory.
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