Controlling the degradation rate of thermoresponsive photo-cross-linked poly(organophosphazene) hydrogels with compositions of depsipeptide and PEG chain lengths

Title
Controlling the degradation rate of thermoresponsive photo-cross-linked poly(organophosphazene) hydrogels with compositions of depsipeptide and PEG chain lengths
Authors
트리무디전창주송수창
Keywords
Thermosensitive; Photo-cross-linkable; Poly(organophosphazene); Depsipeptide; Degradation rate
Issue Date
2011-07
Publisher
Polymer degradation and stability
Citation
VOL 96, NO 7, 1261-1270
Abstract
Thermosensitive and photo-cross-linkable poly(organophosphazenes) containing various amounts of isoleucine ethyl ester, AMPEG550, AMPEG750, aminoethyl methacrylate, and depsipeptide were synthesized, characterized, and were investigated for in vitro and in vivo degradation rates. The aqueous solutions of all polymers showed a sol-gel phase transition behavior against the temperature changes. The polymer degradation rate was majorly affected by the type and degree of the side group’s substitutions. The rate of degradation was initially dependent on the degree of photo-cross-linking, and in later stages on the amounts of the depsipeptide and PEG chain lengths in the polymer network. The amount of the pendant depsipeptide and chain length of the α-amino-ω-methoxy-poly(ethylene glycol) had significant impact on the polymer degradation rates. The polymers with high amount of the depsipeptide, and PEG750 showed fast degradation. These results suggest that the degradation rate of the injectable and dual cross-linkable gels can be tuned to the desired extent and may find wide utilities in various biomedical applications, where the gel strength and degradation rate are needed to be tightly regulated.
URI
http://pubs.kist.re.kr/handle/201004/41206
ISSN
0141-3910
Appears in Collections:
KIST Publication > Article
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