Controlling the degradation rate of thermoresponsive photo-cross-linked poly(organophosphazene) hydrogels with compositions of depsipeptide and PEG chain lengths
- Controlling the degradation rate of thermoresponsive photo-cross-linked poly(organophosphazene) hydrogels with compositions of depsipeptide and PEG chain lengths
- 트리무디; 전창주; 송수창
- Thermosensitive; Photo-cross-linkable; Poly(organophosphazene); Depsipeptide; Degradation rate
- Issue Date
- Polymer degradation and stability
- VOL 96, NO 7, 1261-1270
- Thermosensitive and photo-cross-linkable poly(organophosphazenes) containing various amounts of
isoleucine ethyl ester, AMPEG550, AMPEG750, aminoethyl methacrylate, and depsipeptide were
synthesized, characterized, and were investigated for in vitro and in vivo degradation rates. The aqueous
solutions of all polymers showed a sol-gel phase transition behavior against the temperature changes.
The polymer degradation rate was majorly affected by the type and degree of the side group’s substitutions.
The rate of degradation was initially dependent on the degree of photo-cross-linking, and in later
stages on the amounts of the depsipeptide and PEG chain lengths in the polymer network. The amount of
the pendant depsipeptide and chain length of the α-amino-ω-methoxy-poly(ethylene glycol) had
significant impact on the polymer degradation rates. The polymers with high amount of the depsipeptide,
and PEG750 showed fast degradation. These results suggest that the degradation rate of the injectable and
dual cross-linkable gels can be tuned to the desired extent and may find wide utilities in various
biomedical applications, where the gel strength and degradation rate are needed to be tightly regulated.
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