Monitoring of corticosteroids in cosmetic products manufactured in Korea
- Monitoring of corticosteroids in cosmetic products manufactured in Korea
- 남윤식; 이기수; 박현미; 이강봉
- corticosteroid; cosmetics; LC/MS/MS
- Issue Date
- Some cosmetic products manufactured in Korea have been suspected to contain anti-inflammatory corticosteroids, such as clobetasol propionate and betamethasone dipropionate, for the treatment of eczema, seborrhea and psoriasis, without any indication on the label of the cosmetic products. They were validated and analyzed by a simple high performance liquid chromatography (HPLC) method with ultraviolet diode array (UV-DAD). Linearity was studied with 0.5–10 mg/mL range in both steroids. Good correlation coefficients (r2 0.999) were found, and their limits of quantifications were 0.59 mg/mL and 0.66 mg/mL in clobetasol propionate and betamethasone dipropionate, respectively. At three different concentrations spanning the linear dynamic ranges, mean recoveries were always higher than 93%, and precisions for intra-day and inter-day analyses were both less than 3.5%. The results show 32–96.4 mg/g levels of clobetasol propionate in five different cosmetic products. Also, betamethasone dipropionate in a sample was monitored at the level of 195.1 mg/g
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