Monitoring of corticosteroids in cosmetic products manufactured in Korea

Title
Monitoring of corticosteroids in cosmetic products manufactured in Korea
Authors
남윤식이기수박현미이강봉
Keywords
corticosteroid; cosmetics; LC/MS/MS
Issue Date
2011-09
Publisher
대한화학회
Abstract
Some cosmetic products manufactured in Korea have been suspected to contain anti-inflammatory corticosteroids, such as clobetasol propionate and betamethasone dipropionate, for the treatment of eczema, seborrhea and psoriasis, without any indication on the label of the cosmetic products. They were validated and analyzed by a simple high performance liquid chromatography (HPLC) method with ultraviolet diode array (UV-DAD). Linearity was studied with 0.5–10 mg/mL range in both steroids. Good correlation coefficients (r2 0.999) were found, and their limits of quantifications were 0.59 mg/mL and 0.66 mg/mL in clobetasol propionate and betamethasone dipropionate, respectively. At three different concentrations spanning the linear dynamic ranges, mean recoveries were always higher than 93%, and precisions for intra-day and inter-day analyses were both less than 3.5%. The results show 32–96.4 mg/g levels of clobetasol propionate in five different cosmetic products. Also, betamethasone dipropionate in a sample was monitored at the level of 195.1 mg/g
URI
http://pubs.kist.re.kr/handle/201004/41228
Appears in Collections:
KIST Publication > Conference Paper
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