Analysis on migration and activation of live macrophages on transparent flat and nanostructured titanium

Title
Analysis on migration and activation of live macrophages on transparent flat and nanostructured titanium
Authors
이소영최정일신상원임연민송종한강상수남태현Thomas J. Webster김상현강동우
Keywords
Immunotoxicity; Implant; Macrophage; Titanium; Live cell migration
Issue Date
2011-05
Publisher
Acta Biomaterialia
Citation
VOL 7, NO 5, 2337-2344
Abstract
The immunotoxicity of implanted nanostructured titanium is a paramount issue for vascular, dental and orthopedic applications. However, it has been unclear whether implanted surface nanostructures can inhibit or aggrevate inflammatory responses. Herein, macrophage activation, as evidence of migration, on transparent flat and nanostructured titanium correlated with pro-inflammatory protein synthesis and cytokine release. Through the real-time monitoring of initial cytoskeleton variations, this study identified that macrophage movement was restricted on nanostructured titanium compared to flat titanium surfaces. Furthermore, nanostructured titanium elicited secretion of fewer pro-inflammatory enzyme molecules and cytokines, as well as reduced nitric oxide production. All results collectively indicated that initial macrophage activation can be mitigated by nanoscale surface topography alone, without modification of surface chemistry or stiffness.
URI
http://pubs.kist.re.kr/handle/201004/41234
ISSN
1742-7061
Appears in Collections:
KIST Publication > Article
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