EFFECT OF 1,2,3,4,6-PENTA-O-GALLOYL-beta-D-GLUCOSE ON ELASTASE AND HYALURONIDASE ACTIVITIES AND ITS TYPE II COLLAGEN EXPRESSION
- EFFECT OF 1,2,3,4,6-PENTA-O-GALLOYL-beta-D-GLUCOSE ON ELASTASE AND HYALURONIDASE ACTIVITIES AND ITS TYPE II COLLAGEN EXPRESSION
- 김송자; SANDESH A. SANCHETI; SHRUTI S. SANCHETI; 엄병헌; 유선미; SUNG-YUM SEO
- 1,2,3,4,6-penta-O-galloyl-β-D-glucose; elastase; hyaluronidase; Terminalia chebula; type II collagen
- Issue Date
- Acta Poloniae pharmaceutica.
- VOL 67, NO 2, 145-150
- In the current era, natural products are gaining prime attention in the fields of cosmeceuticals and
pharmaceuticals due to higher safety margins and biological functions, as they have a considerable amount of
potential in treating different ailments. Thus, to find effective elastase and hyaluronidase inhibitors from natural
resources, fifty Korean plants were screened, and the fruit of Terminalia chebula RETZIUS (Combretaceae)
was selected for further structural isolation due to its potent efficacy. The methanol crude extract of the fruits
showed 80% elastase and 87% hyaluronidase enzyme inhibition activities at 1 mg/mL. The crude extract, upon
bioassay-directed fractionation, led to the isolation of compound 1, whose structure was found by spectral
analysis to be 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG). PGG displayed significant elastase and
hyaluronidase inhibitory activities with IC50 values of 57 μg/mL and 0.86 mg/mL, respectively; also, treatment
of PGG on rabbit articular chondrocytes significantly induced the type II collagen expression. Based on elastase
and hyaluronidase inhibitions, and type II collagen expression, it could be suggested that PGG might have
an influence on skin conditions when used cosmetically as an active anti-aging ingredient with no cytotoxicity;
also, it might be beneficial in relieving painful joint conditions, and thus have relevance for treating arthritis.
Therefore, it can be concluded that PGG may prove to be an active ingredient in cosmeceutical and pharmaceutical
formulations, and that it definitely merits further in vivo investigations.
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