Synthesis of an Unnatural Steroid as a Farnesoid X Receptor Antagonist

Title
Synthesis of an Unnatural Steroid as a Farnesoid X Receptor Antagonist
Authors
박효진함정엽원동환진정욱강헌중
Keywords
Farnesoid X receptor; Unnatural steroid; Bile acids; Antagonist
Issue Date
2011-12
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 32, NO 12, 4165-4166
Abstract
In summary, we have carried out the first efficient synthesis of the unnatural steroid pseudo-guggulsterone (PG) and investigated its selective inhibition of FXR activation through a co-transfection bioassay. Further studies to acquire more information about structure-activity relationships are in progress in our laboratory.
URI
http://pubs.kist.re.kr/handle/201004/41382
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
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