Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
- Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
- 신희섭; 전대종; 김상우
- Issue Date
- US-Korea Conference on Science
- Fear can be acquired vicariously through social observation of others suffering from aversive stimuli. We show here that a mouse (observer) develop freezing behavior by observing another (demonstrator) receiving repetitive foot shocks. Observers displayed higher fear responses when demonstrators were socially related to themselves, such as siblings or mating partners. Inactivation of anterior cingulate cortex (ACC), and parafascicular or mediodorsal thalamic nuclei, which comprise medial pain system representing pain affection, significantly impaired this observational fear learning, whereas inactivation of sensory thalamic nuclei had no effect on this learning. The ACC neuronal activities were increased and synchronized with those of the lateral amygdala at theta rhythm frequency during this learning. Furthermore, an ACC–limited deletion of Cav1.2 Ca2+ channels in mice impaired observational fear learning as well as reduced behavioral pain responses. These results demonstrate the functional involvement of affective pain system and Cav1.2 of the ACC in observational social fear.
- Appears in Collections:
- KIST Publication > Conference Paper
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.