A new epicatechin gallate and calpain inhibitory activity from Orostachys japonicus

Title
A new epicatechin gallate and calpain inhibitory activity from Orostachys japonicus
Authors
김형자이준영김성민박다애진창배홍선표이용섭
Keywords
Orostachys japonicus; Crassulaceae; -Calpain; )-Epicatechin 5-gallate
Issue Date
2009-01
Publisher
Fitoterapia : revista di studi ed applicazioni delle piante medicinali
Citation
VOL 80, NO 1, 73-76
Abstract
Calpains are calcium-dependent proteases that cleave a variety of intracellular substrates. The overactivation of μ-calpain is associated with a wide range of disease conditions. To search for calpain inhibitors from natural products, the phytochemical constituents of the ethyl acetate fraction of the whole plant of Orostachys japonicus (Crassulaceae) were studied. The various chromatographic separation of this fraction led to the isolation of a newtannin, (−)-epicatechin 5- gallate (1) along with 9 knowncompounds. Their structureswere elucidated by spectroscopic and chemical analyses. Among them, (−)-epicatechin 5-gallate (1) and kaempferol (9) exhibited moderate inhibitory activity against μ-calpain with IC50 values of 18.0±2.9 and 15.4±2.0 μg/ml, respectively.
URI
http://pubs.kist.re.kr/handle/201004/41860
ISSN
0367-326X
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE