Cerebral hemodynamic responses to seizure in the mouse brain: simultaneous near-infrared spectroscopy-electroencephalography study

Title
Cerebral hemodynamic responses to seizure in the mouse brain: simultaneous near-infrared spectroscopy-electroencephalography study
Authors
이승덕이민아고달권김법민최지현
Keywords
뇌기능 영상; 의광학; Mouse; Near-infrared spectroscopy (NIRS); Electroencephalography (EEG); Seizure; Oxyhemoglobin; Deoxyhemoglobin
Issue Date
2010-05
Publisher
Journal of biomedical optics
Citation
VOL 15, NO 3, 037010-1-037010-8
Abstract
We applied near infrared spectroscopy (NIRS) and electroencephalography (EEG) simultaneously on the mouse brain and investigated the hemodynamic response to epileptic episodes under pharmacologically driven seizure. γ-butyrolactone (GBL) and 4- aminopyridine (4-AP) were applied to induce absence and tonic-clonic seizures, respectively. The epileptic episodes were identified from the single channel EEG and the corresponding hemodynamic changes in different regions of the brain were characterized by multichannel frequency-domain NIRS. Our results are following: (i) the oxyhemoglobin level increases in case of GBL treated mice but not 4-AP treated mice compared to pre-drug state, (ii) the dominant response to each absence seizure is a decrease in deoxyhemolobin, (iii) the phase shift between oxy- and deoxyhemoglobin reduces in GBL treated mice but no 4-AP treated mice, (iv) the spatial correlation of hemodynamics increased significantly in 4-AP treated mice but not in GBL treated mice. Our results shows that spatio-temporal tracking of cerebral hemodynamics using near infrared spectroscopy can be successfully applied to the mouse brain in conjunction with electrophysiological recording, which will support the study of molecular, cellular, and network origin of neurovascular coupling in vivo.
URI
http://pubs.kist.re.kr/handle/201004/41882
ISSN
1083-3668
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