Cerebral hemodynamic responses to seizure in the mouse brain: simultaneous near-infrared spectroscopy-electroencephalography study
- Cerebral hemodynamic responses to seizure in the mouse brain: simultaneous near-infrared spectroscopy-electroencephalography study
- 이승덕; 이민아; 고달권; 김법민; 최지현
- 뇌기능 영상; 의광학; Mouse; Near-infrared spectroscopy (NIRS); Electroencephalography (EEG); Seizure; Oxyhemoglobin; Deoxyhemoglobin
- Issue Date
- Journal of biomedical optics
- VOL 15, NO 3, 037010-1-037010-8
- We applied near infrared spectroscopy (NIRS) and electroencephalography (EEG)
simultaneously on the mouse brain and investigated the hemodynamic response to epileptic
episodes under pharmacologically driven seizure. γ-butyrolactone (GBL) and 4-
aminopyridine (4-AP) were applied to induce absence and tonic-clonic seizures, respectively.
The epileptic episodes were identified from the single channel EEG and the corresponding
hemodynamic changes in different regions of the brain were characterized by multichannel
frequency-domain NIRS. Our results are following: (i) the oxyhemoglobin level increases in
case of GBL treated mice but not 4-AP treated mice compared to pre-drug state, (ii) the
dominant response to each absence seizure is a decrease in deoxyhemolobin, (iii) the phase
shift between oxy- and deoxyhemoglobin reduces in GBL treated mice but no 4-AP treated
mice, (iv) the spatial correlation of hemodynamics increased significantly in 4-AP treated
mice but not in GBL treated mice. Our results shows that spatio-temporal tracking of cerebral
hemodynamics using near infrared spectroscopy can be successfully applied to the mouse
brain in conjunction with electrophysiological recording, which will support the study of
molecular, cellular, and network origin of neurovascular coupling in vivo.
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