Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity

Title
Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity
Authors
감유림이희경임혜원백승근나흥식박혜영
Keywords
T-type calcium channel blocker; Diphenylpiperazine; Formalin test; Neuropathic pain
Issue Date
2010-08
Publisher
Bioorganic & medicinal chemistry
Citation
VOL 18, 5938-5944
Abstract
Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain.
URI
http://pubs.kist.re.kr/handle/201004/41889
ISSN
0968-0896
Appears in Collections:
KIST Publication > Article
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