Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits

Title
Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits
Authors
오상태박병곤함정엽이석준
Keywords
Farnesylacetones; Vasodilatation; Marine natural product; Organic synthesis
Issue Date
2010-07
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 20, NO 14, 4206-4209
Abstract
We have synthesized novel vasodilatation farnesylacetones 1 and 2, which are major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, in 9 steps. A test of the vasodilatation effect of synthetic intermediates and their deprotected compounds on the basilar arteries of rabbits revealed that 14 and 14-1 have a similar dilation effect as their target marine natural products 1 and 2.
URI
http://pubs.kist.re.kr/handle/201004/41892
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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