The diffusional properties of dendrites depend on the density of dendritic spines

Title
The diffusional properties of dendrites depend on the density of dendritic spines
Authors
Fidel SantamariaStefan WilsErik De Schutter조지어거스틴
Keywords
hippocampus; mouse; Purkinje cell; pyramidal cell; signal transduction; synaptic plasticity
Issue Date
2011-08
Publisher
The European journal of neuroscience
Citation
VOL 34, 561-568
Abstract
We combined computational modeling and experimental measurements to determine the influence of dendritic structure on the diffusion of intracellular chemical signals in mouse cerebellar Purkinje cells and hippocamal CA1 pyramidal cells. Modeling predicts that molecular trapping by dendritic spines causes diffusion along spiny dendrites to be anomalous and that the value of the anomalous exponent (dw) is proportional to spine density in both cell types. To test these predictions we combined the local photorelease of an inert dye, rhodamine dextran, with two-photon fluorescence imaging to track diffusion along dendrites. Our results show that anomalous diffusion is present in spiny dendrites of both cell types. Further, the anomalous exponent is linearly related to the density of spines in pyramidal cells and dw in Purkinje cells is consistent with such a relationship. We conclude that anomalous diffusion occurs in the dendrites of multiple types of neurons. Because spine density is dynamic and depends on neuronal activity, the degree of anomalous diffusion induced by spines can dynamically regulate the movement of molecules along dendrites.
URI
http://pubs.kist.re.kr/handle/201004/41908
ISSN
0953816X
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KIST Publication > Article
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