The diffusional properties of dendrites depend on the density of dendritic spines
- The diffusional properties of dendrites depend on the density of dendritic spines
- Fidel Santamaria; Stefan Wils; Erik De Schutter; 조지어거스틴
- hippocampus; mouse; Purkinje cell; pyramidal cell; signal transduction; synaptic plasticity
- Issue Date
- The European journal of neuroscience
- VOL 34, 561-568
- We combined computational modeling and experimental measurements to determine the influence of dendritic structure on the
diffusion of intracellular chemical signals in mouse cerebellar Purkinje cells and hippocamal CA1 pyramidal cells. Modeling predicts
that molecular trapping by dendritic spines causes diffusion along spiny dendrites to be anomalous and that the value of the
anomalous exponent (dw) is proportional to spine density in both cell types. To test these predictions we combined the local
photorelease of an inert dye, rhodamine dextran, with two-photon fluorescence imaging to track diffusion along dendrites. Our results
show that anomalous diffusion is present in spiny dendrites of both cell types. Further, the anomalous exponent is linearly related to
the density of spines in pyramidal cells and dw in Purkinje cells is consistent with such a relationship. We conclude that anomalous
diffusion occurs in the dendrites of multiple types of neurons. Because spine density is dynamic and depends on neuronal activity, the
degree of anomalous diffusion induced by spines can dynamically regulate the movement of molecules along dendrites.
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