Optogenetic probing of functional brain circuitry

Title
Optogenetic probing of functional brain circuitry
Authors
James J. MancusoJinsook Kim이수정Sachiko TsudaNicholas B. H. Chow조지어거스틴
Issue Date
2011-01
Publisher
Experimental physiology
Citation
VOL 96, NO 1, 26-33
Abstract
Recently developed optogenetic technologies offer the promise of high-speed mapping of brain circuitry. Genetically targeted light-gated channels and pumps, such as channelrhodopsins and halorhodopsin, allow optical control of neuronal activity with high spatial and temporal resolution. Optogenetic probes of neuronal activity, such asClomeleon andMermaid, allowlight to be used to monitor the activity of a genetically defined population of neurons. Combining these two complementary sets of optogenetic probes will make it possible to performall-optical circuit mapping. Owing to the improved efficiency and higher speed of data acquisition, this hybrid approach should enable high-throughput mapping of brain circuitry.
URI
http://pubs.kist.re.kr/handle/201004/41911
ISSN
09580670
Appears in Collections:
KIST Publication > Article
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