Optogenetic probing of functional brain circuitry
- Optogenetic probing of functional brain circuitry
- James J. Mancuso; Jinsook Kim; 이수정; Sachiko Tsuda; Nicholas B. H. Chow; 조지어거스틴
- Issue Date
- Experimental physiology
- VOL 96, NO 1, 26-33
- Recently developed optogenetic technologies offer the promise of high-speed mapping of brain
circuitry. Genetically targeted light-gated channels and pumps, such as channelrhodopsins
and halorhodopsin, allow optical control of neuronal activity with high spatial and temporal
resolution. Optogenetic probes of neuronal activity, such asClomeleon andMermaid, allowlight
to be used to monitor the activity of a genetically defined population of neurons. Combining
these two complementary sets of optogenetic probes will make it possible to performall-optical
circuit mapping. Owing to the improved efficiency and higher speed of data acquisition, this
hybrid approach should enable high-throughput mapping of brain circuitry.
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