The Chemical and Hydroxyl Radical Scavenging Activity Changes of Ginsenosides Induced by the Maillard Reaction

Title
The Chemical and Hydroxyl Radical Scavenging Activity Changes of Ginsenosides Induced by the Maillard Reaction
Authors
강기성야마베노리꼬김현영요꼬자와타카코
Keywords
Panax ginseng; Heat-processing; Maillard reaction; Hydroxyl radical
Issue Date
2012-01
Publisher
International Journal of Biomedical and Pharmaceutical Sciences
Citation
VOL 6, 78-83
Abstract
The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,20-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, D20(21)-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of D20(21)-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress.
URI
http://pubs.kist.re.kr/handle/201004/41994
ISSN
1752-3788
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KIST Publication > Article
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