The Chemical and Hydroxyl Radical Scavenging Activity Changes of Ginsenosides Induced by the Maillard Reaction
- The Chemical and Hydroxyl Radical Scavenging Activity Changes of Ginsenosides Induced by the Maillard Reaction
- 강기성; 야마베노리꼬; 김현영; 요꼬자와타카코
- Panax ginseng; Heat-processing; Maillard reaction; Hydroxyl radical
- Issue Date
- International Journal of Biomedical and Pharmaceutical Sciences
- VOL 6, 78-83
- The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical
generator, 2,20-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells
was investigated to identify the structural characteristics of sapogenins to have renoprotective effects.
Of the tested sapogenins, D20(21)-protopanaxatriol showed the strongest protective effect against the
AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of D20(21)-protopanaxatriol
than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were
important for renoprotective effect of sapogenin against oxidative stress.
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