Protective effect of ginseng sapogenins against 2,2'-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage
- Protective effect of ginseng sapogenins against 2,2'-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage
- 강기성; 김현영; 유혜현; 박향란; 함정엽; 양현옥; 박정일
- Panax ginseng; Renoprotective activity; Ginsenoside; Sapogenin
- Issue Date
- Bioorganic & medicinal chemistry letters
- VOL 22, NO 1, 634-637
- The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical
generator, 2,20-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells
was investigated to identify the structural characteristics of sapogenins to have renoprotective effects.
Of the tested sapogenins, D20(21)-protopanaxatriol showed the strongest protective effect against the
AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of D20(21)-protopanaxatriol
than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were
important for renoprotective effect of sapogenin against oxidative stress.
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