Protective effect of ginseng sapogenins against 2,2'-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage

Title
Protective effect of ginseng sapogenins against 2,2'-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage
Authors
강기성김현영유혜현박향란함정엽양현옥박정일
Keywords
Panax ginseng; Renoprotective activity; Ginsenoside; Sapogenin
Issue Date
2012-01
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 22, NO 1, 634-637
Abstract
The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,20-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, D20(21)-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of D20(21)-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress.
URI
http://pubs.kist.re.kr/handle/201004/41995
ISSN
0960894X
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KIST Publication > Article
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