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dc.contributor.author강기성-
dc.contributor.author김현영-
dc.contributor.author유혜현-
dc.contributor.author박향란-
dc.contributor.author함정엽-
dc.contributor.author양현옥-
dc.contributor.author박정일-
dc.date.accessioned2015-12-03T00:46:12Z-
dc.date.available2015-12-03T00:46:12Z-
dc.date.issued201201-
dc.identifier.citationVOL 22, NO 1, 634-637-
dc.identifier.issn0960894X-
dc.identifier.other36807-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/41995-
dc.description.abstractThe effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,20-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, D20(21)-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of D20(21)-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress.-
dc.publisherBioorganic & medicinal chemistry letters-
dc.subjectPanax ginseng-
dc.subjectRenoprotective activity-
dc.subjectGinsenoside-
dc.subjectSapogenin-
dc.titleProtective effect of ginseng sapogenins against 2,2'-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage-
dc.typeArticle-
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