Hepatoprotective Effect of Handaeri-gomchi (Ligularia fischeri var. spiciformis Nakai) Extract against Chronic Alcohol-induced Liver
Damage in Rats
- Hepatoprotective Effect of Handaeri-gomchi (Ligularia fischeri var. spiciformis Nakai) Extract against Chronic Alcohol-induced Liver
Damage in Rats
- 유지혜; 사랑게렐; 김상민; 전나라; 윤지호; 강경수; 조은혜; 이샛별; 노주원
- Ligularia fischeri; chronic alcohol; hepatoprotection; oxidative stress; antioxidative capacity; Ligularia fischeri var. spiciformis Nakai
- Issue Date
- Food science and biotechnology
- VOL 20, NO 6, 1655-1661
- Handaeri-gomchi (Ligularia fischeri var.
spiciformis Nakai) (LF) is well known as a medicinal plant
in Korea, especially to treat a variety of human disease
including hepatic function failure. In this study, we
examined the activity of LF extract against the liver injuries
and oxidative stress by chronic alcohol in Spargue-Dawley
rats. Severe liver damage caused by alcohol intake with
increasing activity of hepatic markers was decreased in the
group of rats fed LF extract. The results were confirmed
through hematoxylin and eosin staining. Antioxidative
capacity was decreased by alcohol but it was recovered by
LF extract. Elevated indicators of oxidative stress by chronic
alcohol were diminished in the group of LF extract.
Furthermore, LF extracts increased antioxidative capacity
and the activity of antioxidant enzymes. In conclusion, LF
extract has a protective effect against chronic alcohol
hepatotoxicity, suggesting it could be developed as a
functional food or medicine for protection of liver disease.
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