Hepatoprotective Effect of Handaeri-gomchi (Ligularia fischeri var. spiciformis Nakai) Extract against Chronic Alcohol-induced Liver Damage in Rats

Title
Hepatoprotective Effect of Handaeri-gomchi (Ligularia fischeri var. spiciformis Nakai) Extract against Chronic Alcohol-induced Liver Damage in Rats
Authors
유지혜사랑게렐김상민전나라윤지호강경수조은혜이샛별노주원
Keywords
Ligularia fischeri; chronic alcohol; hepatoprotection; oxidative stress; antioxidative capacity; Ligularia fischeri var. spiciformis Nakai
Issue Date
2011-12
Publisher
Food science and biotechnology
Citation
VOL 20, NO 6, 1655-1661
Abstract
Handaeri-gomchi (Ligularia fischeri var. spiciformis Nakai) (LF) is well known as a medicinal plant in Korea, especially to treat a variety of human disease including hepatic function failure. In this study, we examined the activity of LF extract against the liver injuries and oxidative stress by chronic alcohol in Spargue-Dawley rats. Severe liver damage caused by alcohol intake with increasing activity of hepatic markers was decreased in the group of rats fed LF extract. The results were confirmed through hematoxylin and eosin staining. Antioxidative capacity was decreased by alcohol but it was recovered by LF extract. Elevated indicators of oxidative stress by chronic alcohol were diminished in the group of LF extract. Furthermore, LF extracts increased antioxidative capacity and the activity of antioxidant enzymes. In conclusion, LF extract has a protective effect against chronic alcohol hepatotoxicity, suggesting it could be developed as a functional food or medicine for protection of liver disease.
URI
http://pubs.kist.re.kr/handle/201004/41996
ISSN
12267708
Appears in Collections:
KIST Publication > Article
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