Thermosensitive/magnetic poly(organophosphazene) hydrogel as a long-term magnetic resonance contrast platform

Title
Thermosensitive/magnetic poly(organophosphazene) hydrogel as a long-term magnetic resonance contrast platform
Authors
김장일전창주김보라홍지민조정교이승훈송수창
Keywords
Phosphazene; Magnetic hydrogel; Contrast agents; MRI; Hydrophobic interaction; Long-term MR imaging
Issue Date
2012-01
Publisher
Biomaterials
Citation
VOL 33, NO 1, 218-224
Abstract
A thermosensitive/magnetic poly(organophosphazene) hydrogel (a magnetic hydrogel) was designed and synthesized for long-term magnetic resonance (MR) imaging. To turn a thermosensitive poly(organophosphazene) hydrogel (an original hydrogel) into a long-term MR contrast platform, cobalt ferrite (CoFe2O4) nanoparticles, which have hydrophobic surfaces, were bound to the original hydrogel via interactions between the hydrophobic surfaces of the nanoparticles and the L-isoleucine ethyl esters of the polymer. The magnetic hydrogel showed extremely low cytotoxicity and adequate magnetic properties for use in long-term MR imaging, in addition to possessing the same properties of the original hydrogel, such as viscosity, thermosensitivity, biodegradability, biocompatibility, a reversible sol-to-gel phase transition near body temperature, and injectability. The magnetic hydrogel was injected into a rat brain using stereotactic surgery. After the injection, the applicable potentiality as a long-term MR contrast platform was successfully estimated over 4e5 weeks. Consequently, it was shown that a magnetic hydrogel as a long-term MR contrast platform has the potential to be applied in a long-term theranostic hydrogel system. Furthermore, it is expected that this platform can be useful in the clinical field of incurable diseases due to either surgical difficulties or lethality, such as with brain tumors, when the platform is combined with therapeutic drugs for long-term MR theragnosis in further studies.
URI
http://pubs.kist.re.kr/handle/201004/42034
ISSN
01429612
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KIST Publication > Article
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