Bis[(2,2-dimethylpropanoyloxy)methyl] {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonate-succinic acid (2/1)

Title
Bis[(2,2-dimethylpropanoyloxy)methyl] {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonate-succinic acid (2/1)
Authors
정성엽하정명김일원
Issue Date
2012-03
Publisher
Acta crystallographica Section E, Structure reports online. [computer file]
Citation
VOL 68, NO 3, o809-o810
Abstract
The title compound, C20H32N5O8P·0.5C4H6O4, is composed of two 9-{2-[bis(pivaloyloxymethoxy)phosphinylmethoxy]ethyl}- adenine, commonly known as adefovir dipivoxil (AD), molecules linked to the carboxylic acid groups of succinic acid (SA). The asymmetric unit contains one molecule of AD and half a molecule of SA, which sits on an inversion center. Both adenine units in the two AD molecules make AD–SA N—H···O and SA–AD O—H···N hydrogen bonds to SA. In addition, the intermolecular AD–AD N—H···O—P hydrogen bond serves to stabilize the cocrystal. There is also a π-π stacking interaction [interplanar spacing 3.34 (19) A ° ] between adjacent inversion-related adenine groups.
URI
http://pubs.kist.re.kr/handle/201004/42069
ISSN
16005368
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KIST Publication > Article
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