Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats
- Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats
- 김준기; 박상원; 강정우; 김유진; 이성열; 신준식; 이상호; 이선미
- GCSB-5; Osteoarthritis
- Issue Date
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
- VOL 2012, 730907-1-730907-11
- Therapeutic effects of GCSB-5 on osteoarthritis were measured by the amount of glycosaminoglycan in rabbit articular cartilage
explants in vitro, in experimental osteoarthritis induced by intra-articular injection of monoiodoacetate in rats in vivo. GCSB-5
was orally administered for 28 days. In vitro, GCSB-5 inhibited proteoglycan degradation. GCSB-5 significantly suppressed the
histological changes in monoiodoacetate-induced osteoarthritis. Matrix metalloproteinase (MMP) activity, as well as, the levels of
serum tumor necrosis factor-α, cyclooxygenase-2, inducible nitric oxide synthase protein, and mRNA expressions were attenuated
by GCSB-5, whereas the level of interleukin-10 was potentiated. By GCSB-5, the level of nuclear factor-κB p65 protein expression
was significantly attenuated but, on the other hand, the level of inhibitor of κB-α protein expression was increased. These results
indicate that GCSB-5 is a potential therapeutic agent for the protection of articular cartilage against progression of osteoarthritis
through inhibition of MMPs activity, inflammatory mediators, and NF-κB activation.
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