Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice

Title
Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice
Authors
이석찬Touqeer AhmedSoojung LeeHuisu KimSukwoo ChoiDuk-Soo KimSang Jeong Kim조제원신희섭
Issue Date
2012-02
Publisher
Nature neuroscience
Citation
VOL 15, NO 2, 308-314
Abstract
The mediodorsal thalamic nucleus has been implicated in the control of memory processes. However, the underlying neural mechanism remains unclear. Here we provide evidence for bidirectional modulation of fear extinction by the mediodorsal thalamic nucleus. Mice with a knockout or mediodorsal thalamic nucleus–specific knockdown of phospholipase C b4 exhibited impaired fear extinction. Mutant mediodorsal thalamic nucleus neurons in slices showed enhanced burst firing accompanied by increased T-type Ca2+ currents; blocking of T channels in vivo rescued the fear extinction. Tetrode recordings in freely moving mice revealed that, during extinction, the single-spike (tonic) frequency of mediodorsal thalamic nucleus neurons increased in wild-type mice, but was static in mutant mice. Furthermore, tonic-evoking microstimulations of the mediodorsal thalamic nucleus, contemporaneous with the extinction tones, rescued fear extinction in mutant mice and facilitated it in wild-type mice. In contrast, burst-evoking microstimulation suppressed extinction in wild-type mice, mimicking the mutation. These results suggest that the firing mode of the mediodorsal thalamic nucleus is critical for the modulation of fear extinction.
URI
http://pubs.kist.re.kr/handle/201004/42136
ISSN
10976256
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KIST Publication > Article
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